Soluble FaS and FaS-ligand PlaSma levelS in Heart tranSPlant reciPientS treated witH neoral or tacrolimuS
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چکیده
The plasma levels of soluble antiapoptotic Fas (sFas) and proapoptotic Fas-ligand (sFasl) proteins were studied in heart transplant recipients at one-month follow-up. The patients were treated with Neoral (n=18) or Tacrolimus (n=12) and concomitant immunosuppressive drugs. The sFas and sFasl levels were detected by ElISA. The values were related to treatment with Neoral or Tacrolimus in stable patients and in patients with acute rejection episodes (treated with methylprednisolone; ≥IB), and also to antirejection treatment with methylprednisolone or ATG/OkT3. The results showed no significant changes in sFas and sFasl levels in the stable recipients and in the patients experiencing acute rejection treated with methylprednisolone, regardless of treatment with Neoral or Tacrolimus. However, with antirejection therapy, both sFas and sFasl levels increased in the patients given ATG or OkT3, but not in those treated with methylprednisolone.
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